Nematode Biology

School of Biological Sciences
University of Bristol
Tyndall Avenue
Bristol BS8 1TQ
+44 (0)117 394 1203
email: Mark Viney

Publications

  • Papers
  • Viney, M.E. & Harvey, S.C. (2017) Reimagining pheromone signalling in the model nematode Caenorhabditis elegans. PLoS Genetics, in press.
  • Wharam, B., Weldon, L., & Viney, M.E. (2017) Pheromone modulates two phenotypically plastic traits – adult reproduction and larval diapause – in the nematode Caenorhabditis elegans. BMC Evolutionary Biology, 17, 197.
  • Viney, M.E. (2017) The genomic basis of nematode parasitism. Briefings in Functional Genomics, 2017 elx010. doi: 10.1093/bfgp/elx010
  • Abolins S., King, E., Lazarou, L., Weldon, L., Hughes, L., Drescher P., Raynes, J., Hafalla, J., Viney, M.E. & Riley, E.M. (2017) The comparative immunology of wild and laboratory mice Mus musculus domesticus. Nature Communications, 8, 14811.
  • Viney, M.E. (2017) How can we understand the genomic basis of nematode parasitism? Trends in Parasitology, 33, 444-452.
  • McCallum, H., Fenton, A., Hudson, P.J., Lee, B., Levick, B., Norman, R., Perkins, S.E., Viney, M.E., Wilson, A.J. & Lello, J. (2017) Breaking beta: deconstructing the parasite transmission function. Philosophical Transactions of the Royal Society of London Series B, 372, 20160084.
  • Viney, M.E. (2017) Strongyloides. Parasitology, 144, 259-262.
  • Viney, M.E. & Kikuchi, T. (2017) Strongyloides ratti and S. venezuelensis – rodent models of Strongyloides infection. Parasitology, 144, 285-294.
  • Hunt V.L., Tsai, I.J., Selkirk, M.E. & Viney, M.E. (2017) The genome of Strongyloides spp. gives insights into protein families with a putative role in nematode parasitism. Parasitology, 144, 343-358.
  • Hunt V.L., Asai I.J., Coghlan A., Reid A.J., Holroyd N., Foth B.J., Tracey A., Cotton J.A., Stanley E.J., Beasley H., Bennett H., Brooks K., Harsha B., Kajitani R., Kulkarni A., Harbecke D., Nagayasu E., Nichol S., Ogura Y., Quail M.A., Randle N., Xia D., Brattig N.W., Soblik H., Ribeiro D.M., Sanchez-Flores A., Hayashi T., Itoh T., Denver D.R., Grant W.N, Stoltzfus J.D., Lok J.B., Murayama H., Wastling J., Streit A., Kikuchi T., Viney, M.E. & Berriman M. (2016) The genomic basis of parasitism in the Strongyloides clade of nematodes. Nature Genetics, 48, 299-307.
  • Mable, B.K., Kilbride, E., Viney, M.E. & Tinsley, R.C. (2015) Copy number variation and genetic diversity of MHC Class IIb alleles in an alien population of Xenopus laevis. Immunogenetics, 67, 591-603.
  • Tinsley, R.C., Stott, L.C., Viney, M.E., Mable, B.K. & Tinsley, M.C. (2015) Extinction of an introduced warm climate alien species, Xenopus laevis, by extreme weather events. Biological Invasions,17, 3183-3195.
  • Weldon, L., Abolins, S., Lenzi, L., Bourne, C., Riley, E.M. & Viney, M.E. (2015) The gut microbiota of wild mice. PLoS One, 10, e0134643.
  • Diaz, S.A. & Viney, M.E. (2015) The evolution of plasticity of dauer larva developmental arrest in the nematode Caenorhabditis elegans. Ecology and Evolution, 5, 1343-1353.
  • Viney, M.E., Lazarou, L. & Abolins, S.R. (2015) The laboratory mouse and wild immunology. Parasite Immunology, 37, 267-273.
  • Viney, M.E. (2014) The failure of genomics in biology. Trends in Parasitology, 30, 319-321.
  • Diaz, S.A. & Viney, M.E. (2014) Genotypic-specific variance in Caenorhabditis elegans lifetime fecundity. Ecology and Evolution, 4, 2058-2069.
  • Diaz, S.A. Lloyd-Jones, G. Spinner, W. Wharam, B. & Viney, M.E. (2014) Diverse and potentially manipulative signalling with ascarosides in the model nematode C. elegans. BMC Evolutionary Biology, 14, 46.
  • Viney, M.E. & Reece, S.E. (2013) Adaptive noise. Proceedings of the Royal Society of London Series B, 280, 20131104.
  • Viney, M.E. & Graham, A.L. (2013) Patterns and processes in parasite co-infection in animals and humans. Advances in Parasitology, 82, 321-369.
  • Ellis, R.J., Bruce, K.D., Jenkins, C., Stothard, R., Ajarova, L., Mugisha, L. & Viney, M.E. (2013). Comparison of the distal gut microbiota from people and animals in Africa. PLoS One, 8, e54783.
  • Lello, J., Knopp, S., Mohammed, K.A., Khamis, I.S., Utzinger J. & Viney, M.E. (2013) The role of co-infection in infection risk for school-aged children in Zanzibar. Proceedings of the Royal Society of London Series B, 280, 20122813.
  • Tinsley, R.C., Stott, L., York, J., Everard, A., Chapple, S, Jackson, J., Viney, M.E. & Tinsley, M. (2012) Acquired immunity protects against helminth infection in a natural host population: long-term field and laboratory evidence. International Journal for Parasitology, 42, 931-938.
  • Viney, M.E. & Diaz, A. (2012) Phenotypic plasticity in nematodes : evolutionary and ecological significance. Worm, 1, 98-106.
  • Spinner, W.G., Thompson, F.J., Emery, D.C. & Viney, M.E. (2012) Characterisation of genes with a putative key role in the parasitic lifestyle of the nematode Strongyloides ratti. Parasitology, 139, 1317-1328.
  • Viney, M.E. & Cable, J. (2011) Macroparasite life-histories. Current Biology, 21, R767-R774.
  • Li, X,, Shao, H., Junio, A., Nolan, T.J., Massey, H.C., Pearce, E.A., Viney, M.E. & Lok, J.B. (2011) Transgenesis in the parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology, 179, 114-119.
  • Abolins, S.R., Pocock, M.J.O., Hafalla, J.C.R., Riley, E.M. & Viney, M.E. (2011) Measures of immune function of wild mice, Mus musculus. Molecular Ecology, 20, 881-892.
  • Gorr, T.A., Wichmann, D., Hu, J., Hermes-Lima M., Welker, A.F., Terwilliger, N., Wren, J.F. Viney, M.E., Morris, S., Nilsson, G.E., Deten, A. & Soliz, J. (2010) Hypoxia tolerance in animals: Biology and application. Physiological and Biochemical Zoology, 83, 733-752.
  • O'Meara, H., Barber, R., Mello, L.V., Sangaralingam, A., Viney, M.E. & Paterson, S. (2010) Response of the Strongyloides ratti transcriptome to host immunological environment. International Journal for Parasitology, 40, 1609-1617.
  • Jeffries, R., Shaw, S.E., Willesen, J.,Viney, M.E. & Morgan, E.R. (2010) Elucidating the spread of the emerging canid nematode Angiostrongylus vasorum between Palaearctic and Nearctic ecozones. Infection, Genetics and Evolution, 10, 561-568.
  • Fenton, A., Viney, M.E. & Lello, J. (2010) Interspecific parasite interactions in ecological data: patterns and process. Ecology Letters 13, 606-615.
  • Nemetschke L., Eberhardt A.G., Viney, M.E. & Streit, S. (2010) A genetic map of the animal-parasitic nematode Strongyloides ratti. Molecular & Biochemical Parasitology 169, 124-127.
  • Harvey, S.C. Barker, G.L.A., Shorto, A. & Viney, M.E. (2009) Variation in gene expression in the early development of dauer larvae of Caenorhabditis elegans. BMC Genomics, 10, 325
  • Viney, M.E., Bullock, A.J., Day, M.J. & MacNeil, S.J. (2009) The co-culture of intestinal epithelial and stromal cells in 3D collagen-based environments. Regenerative Medicine, 4, 397-406.
  • Viney, M.E. (2009) How did parasitic worms evolve? BioEssays, 31, 496-499.
  • Bleay, C., Wilkes, C.P., Paterson, S. & Viney, M.E. (2009) The effect of infection history on the fitness of the gastrointestinal nematode Strongyloides ratti. Parasitology, 136, 567-577.
  • Thompson, F.J., Barker, G.L.A., Nolan, T., Gems, D. & Viney, M.E. (2009) Transcript profiles of long- and short-lived adults implicate protein synthesis in evolved differences in ageing in the nematode Strongyloides ratti. Mechanisms of Ageing and Development, 130, 167-172.
  • Jefferies,. R., Shaw, S.E., Viney, M.E. & Morgan, E.R. (2009) Angiostrongylus vasorum from South America and Europe represent distinct lineages. Parasitology, 136, 107-115.
  • Evans, H., Mello, L.V., Fang, Y., Wit, E., Thompson, F.J., Viney, M.E. & Paterson, S. (2008) Microarray analysis of gender- and parasite-specific gene transcription in Strongyloides ratti. International Journal for Parasitology, 38, 1329-1341.
  • Paterson, S., Wilkes, C.P., Bleay, C. & Viney, M.E. (2008) Immunological responses elicited by different infection regimes with Strongyloides ratti. PLoS One, 3, e2509.
  • Thompson, F.J., Barker, G.L.A., Hughes, L., & Viney, M.E. (2008) Genes important in the parasitic life of the nematode Strongyloides ratti. Molecular and Biochemical Parasitology, 158, 112-119.
  • Viney, M.E. & Thompson, F.J. (2008) Two hypotheses to explain why RNA interference does not work in animal parasitic nematodes. International Journal for Parasitology, 38, 43-47.
  • Harvey, S.C., Shorto, A. & Viney, M.E. (2008) Quantitative genetic analysis of life-history traits of Caenorhabditis elegans in stressful environments. BMC Evolutionary Biology, 8, 15.
  • Bleay, C., Wilkes C.P., Paterson S. & Viney, M.E. (2007) Density-dependent immune responses against the gastrointestinal nematode Strongyloides ratti. International Journal for Parasitology, 37, 1501-1509.
  • Wilkes, C.P., Bleay, C., Paterson, S. & Viney, M.E. (2007) The immune response during a Strongyloides ratti infection of rats. Parasite Immunology, 29, 339-346.
  • Harvey, S.C. & Viney, M.E. (2007) Thermal variation reveals natural variation between isolates of Caenorhabditis elegans. Journal of Experimental Zoology B: Molecular and Developmental Evolution, 308B, 409-416.
  • Thompson, F.J., Barker, G.L.A., Hughes, L., Wilkes, C.P., Coghill J. & Viney, M.E. (2006) A microarray analysis of gene expression in the free-living stages of the parasitic nematode Strongyloides ratti. BMC Genomics, 7, 157-177.
  • Gardner, M.P., Gems, D. & Viney, M.E. (2006) Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution. Aging Cell, 5, 315-323.
  • Viney, M.E., Steer, M.D. & Wilkes, C.P. (2006) The reversibility of constraints on size and fecundity in the parasitic nematode Strongyloides ratti. Parasitology, 133, 477-483.
  • Viney, M.E. (2006) The biology and genomics of Strongyloides. Medical Microbiology and Immunology, 195, 49-54.
  • Viney, M.E. (2006) Modelling nematode infections? Parasite Immunology, 28, 239-241.
  • Viney, M.E., Thompson, F.J. & Crook. M. (2005) TGF-β and the evolution of nematode parasitism. International Journal for Parasitology, 35, 1473-1475.
  • Viney, M.E., Riley, E.M. & Buchanan, K.L. (2005) Optimal immune responses: immunocompetence revisited. Trends in Ecology and Evolution, 20, 665-669.
  • Crook, M. & Viney, M.E. (2005) The effect of non-immune stresses on the development of Strongyloides ratti. Parasitology, 131, 383-392.
  • Thompson, F.J., Mitreva, M., Barker, G.L.A, Martin, J., Waterston, R.H., McCarter, J.P. Viney, M.E. (2005) An expressed sequence tag analysis of the life-cycle of the parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology, 142, 32-46.
  • Crook, M., Thompson, F.J., Grant, W.N. & Viney M.E. (2005) The role of daf-7 in the development of Strongyloides ratti and Parastrongyloides trichosuri. Molecular and Biochemical Parasitology, 139, 213-223.
  • Viney, M.E., Brown, M., Omoding, N.E., Bailey, J.W., Gardner, M.P., Roberts, E., Morgan, D., Elliott, A.M. & Whitworth, J.A.G. (2004) Why does HIV infection not lead to disseminated Strongyloidiasis? Journal of Infectious Diseases, 190, 2175-2180.
  • Gardner, M.P., Gems, D. & Viney, M.E. (2004) Aging in a very short-lived nematode. Experimental Gerontology, 39, 1267-1276.
  • Wilkes, C.P. & Viney, M.E. (2004) An attempt to select Strongyloides ratti for resistance to the host immune response. Parasite Immunology, 26, 63-66.
  • Fenton, A., Paterson, S., Viney, M.E., & Gardner, M.P. (2004) Determining the optimal developmental route of Strongyloides ratti: an evolutionarily stable strategy approach. Evolution, 58, 989-1000.
  • Wilkes, C.P., Thompson, F.J., Gardner, M.P., Paterson, S. & Viney, M.E. (2004) The effect of the host immune response on the parasitic nematode Strongyloides ratti. Parasitology, 128, 661-669.
  • Viney, M.E. & Franks, N.R. (2004) Is dauer pheromone of Caenorhabditis elegans really a pheromone? Naturwissenschaften, 91, 123-124.
  • Viney, M.E., Gardner, M.P. & Jackson, J.A. (2003) Variation in Caenorhabditis elegans dauer larva formation. Development, Growth and Differentiation, 45, 389-396.
  • Guinnee, M.A., Gemmill, A.W., Chan, B.H.K., Viney, M.E. & Read, A.F. (2003) Host immune status affects maturation time in two nematode species – but not as predicted by a simple life history model. Parasitology, 127, 507-512.
  • Paterson, S. & Viney, M.E. (2003) Functional consequences of genetic diversity in Strongyloides ratti infections. Proceedings of the Royal Society of London Series B, 270, 1023-1032.
  • Viney, M.E., Green, L.D., Brookes, J.A. & Grant, W.N. (2002) Chemical mutagenesis of the parasitic nematode Strongyloides ratti to isolate Avermectin resistant mutants. International Journal for Parasitology, 32, 1677-1682.
  • Paterson, S. & Viney, M.E. (2002) Host immune responses are necessary for density-dependence in nematode infections. Parasitology,125, 283-292.
  • Viney, M.E. (2002) How do host immune responses affect nematode infections? Trends in Parasitology, 18, 63-66.
  • Dorris, M., Viney, M.E. & Blaxter, M.L. (2002) Molecular phylogenetic analysis of the genus Strongyloides and related nematodes. International Journal for Parasitology, 32, 1507-1517.
  • Grant, W.N. & Viney, M.E. (2001) Post genomic nematode parasitology . International Journal for Parasitology, 31, 879-888.
  • Harvey, S.C. & Viney, M.E. (2001) Sex determination in the parasitic nematode Strongyloides ratti. Genetics, 158, 1527-1533.
  • West, S.A., Gemmill, A.W., Graham, A., Viney, M.E. & Read, A.F. (2001) Immune stress and facultative sex in a parasitic nematode. Journal of Evolutionary Biology, 14, 333-337.
  • Dichtel, M-L., Louvet-Vallee, S., Viney, M.E., Felix, M-A. & Sternberg, P.W. (2001) Control of vulval cell division number in the nematode Oscheius / Dolichorhabditis sp. CEW1. Genetics, 157, 183-197.
  • Paterson, S. & Viney, M.E. (2000) The interface between epidemiology and population genetics. Parasitology Today, 16, 528-532.
  • Harvey, S.C., Gemmill, A.W., Read, A.F. & Viney, M.E. (2000) The control of morph development in the parasitic nematode Strongyloides ratti. Proceedings of the Royal Society of London Series B, 267, 2057-2063.
  • Paterson, S., Fisher, M.C. & Viney, M.E. (2000) Inferring infection processes of a parasitic nematode using population genetics. Parasitology,120, 185-194.
  • Gemmill, A.W., Viney, M.E. & Read, A.F. (2000) The evolutionary ecology of host-specificity: experimental studies with Strongyloides ratti. Parasitology, 120, 429-437.
  • Harvey, S.C., Paterson, S. & Viney, M.E. (1999) Heterogeneity in the distribution of Strongyloides ratti infective stages among the faecal pellets of rats. Parasitology, 119, 227-235.
  • Viney, M.E. (1999) Exploiting the life-cycle of Strongyloides ratti. Parasitology Today, 15, 231-235.
  • Viney, M.E. (1998) Nematode population genetics. Journal of Helminthology, 72, 281-283.
  • Fisher, M.C. & Viney, M.E. (1998) The population genetic structure of the facultatively sexual parasitic nematode Strongyloides ratti in wild rats. Proceedings of the Royal Society of London Series B, 265, 703-709.
  • Gemmill, A.W., Viney, M.E. & Read, A.F. (1997) Host immune status determines sexuality in a parasitic nematode. Evolution, 51, 393-401.
  • Fisher, M.C. & Viney, M.E. (1996) Microsatellites of the parasitic nematode Strongyloides ratti. Molecular and Biochemical Parasitology, 80, 221-224.
  • Read, A.F. & Viney, M.E. (1996) Nematode immunogenetics - why bother? Parasitology Today, 12, 337-343.
  • Viney, M.E. (1996) Developmental switching in the parasitic nematode Strongyloides ratti. Proceedings of the Royal Society of London Series B, 263, 201-208.
  • Viney, M.E. (1994) A genetic analysis of reproduction in Strongyloides ratti. Parasitology, 109, 511-515.
  • Viney, M.E., Matthews, B.E. & Walliker, D. (1993) Mating in the parasitic nematode Strongyloides ratti: Proof of genetic exchange. Proceedings of the Royal Society of London Series B, 254, 213-219.
  • Ashford, R.W., Barnish, G. & Viney, M.E. (1992) Strongyloides fuelleborni kellyi: Infection and Disease in Papua New Guinea. Parasitology Today, 8, 314-318.
  • Viney, M.E., Matthews, B.E. & Walliker, D. (1992) On the biological and biochemical nature of cloned populations of Strongyloides ratti. Journal of Helminthology, 66, 45-52.
  • Viney, M.E., Barnish, G. & Ashford, R.W. (1991) A taxonomic study of Strongyloides Grassi, 1879 (Nematoda) with special reference to Strongyloides fuelleborni von Linstow, 1905 in man in Papua New Guinea and the description of a new subspecies. Systematic Parasitology, 18, 95-109.
  • Viney, M.E. & Ashford, R.W. (1990) The use of isoenzyme electrophoresis in the taxonomy of Strongyloides. Annals of Tropical Medicine & Parasitology, 84, 35-47.
  • Viney, M.E. & Ashford, R.W. (1990) The ultrastructure of the peri-vulval region of Strongyloides cebus. Journal of Helminthology, 64, 23-28.
  • Hollister, W.S., Canning, E.U. & Viney, M.E. (1989) Prevalence of antibodies to Encephalitozoon cuniculi in stray dogs as determined by an ELISA. Veterinary Record, 124, 332-336.
  • Invited book chapters
  • Viney, M.E. & Riley, E.M. (2014) From immunology to eco-immunology: more than a new name, pp1-19. In: Eco-immunology: evolutive aspects and future perspectives (eds D. Malagoli and E. Ottaviani). Springer, UK.
  • Viney, M.E. (2013) Life history plasticity and responses to host defence, 15-29. In: Parasitic Nematodes: Molecular Biology, Biochemistry and Immunology 2nd edition (eds. M.W. Kennedy and W. Harnett). CABI Publishing.
  • Grant, W. & Viney, M.E. (2011). The dauer phenomenon, pp 99-125. In: Molecular and Physiological Basis of Nematode Survival (eds R.N. Perry and D.A. Wharton). CABI Publishing, Wallingford, UK.
  • Viney, M.E. & Lok, J.B. (2007) Strongyloides spp. WormBook, ed. The C. elegans Research Community, WormBook, doi/10.1895/wormbook.1.7.1, http://www.wormbook.org
  • Gardner, M.P.,Viney, M.E. & Gems, D. (2006) Strongyloides ratti: A nematode with extraordinary plasticity in aging, pp 229-239. In: Handbook of models for human aging (ed P. Michael Conn). Academic Press.
  • Viney, M.E. (2002) Environmental control of nematode life-cycles, pp 111-128. In: Behavioural Ecology of Parasites (eds E. Lewis, J.F. Campbell, M. Sukhdeo). CABI Publishing.
  • Viney, M.E. (2001) Diversity in populations of parasitic nematodes and its significance, pp 83-102. In: Parasitic nematodes: Molecular biology, biochemistry and immunology (eds M.W. Kennedy and W. Harnett). CABI Publishing.
  • Others
  • Viney, M.E. (2012) A self-reflecting scientist’s look at Science and at the Humanities (in Arabic). Kalamon (Kalamon.org) (in press).
  • Viney, M.E. (2012) Mechanisms of life history evolution. The genetics and physiology of life history traits and trade-offs, edited by T. Flatt & A. Heyland (Book Review). Quarterly Review of Biology, 87, 255-256.
  • Viney, M.E. (2012) The evolutionary history of nematodes as revelaed in stone, amber and mummies (Book Review). Parasitology, 139, 137.
  • Booth, M., Graham, A & Viney, M.E. (2008) Parasite co-infections: challenges and solutions, (edited by M. Booth, A. Graham & M. Viney). Supplement to Parasitology, 135 (7).
  • Viney, M.E. & Read, A.F. (2003) Parasite variation: Immunological and ecological significance, (edited by M.E. Viney & A.F. Read). Supplement to Parasitology, 38 and Preface (38, S1-S2 )
  • Viney, M.E. (2002) Wolbachia and river blindness. Trends in Parasitology, 18, 244.
  • Viney, M.E. (2002) Developing worms need the host immune response. Trends in Parasitology, 18, 57.
  • Viney, M.E. (2002) A paradoxical protozoan and its virulence. Trends in Parasitology, 18, 6.
  • Viney, M.E. & Read, A.F. (2002) So what if parasites vary? Trends in Parasitology, 18, 2.
  • Viney, M.E. (in press) Book review. Journal of Fish Biology, 58, 1481-1482
  • Viney, M.E. (2001) Book review. Molecular Biotechnology, 17, 188.
  • Viney, M.E. (in press) Caenorhabditis elegans. In: Encyclopaedia of Genetics (edited by E.C.R. Reeve), pp 845-848, Fitzroy Dearborn Publishers London.
  • Viney, M.E. (1992) Book review. Genet. Res. Camb., 59, 70.
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